Tamoxifen FAQ
What is Tamoxifen?
Tamoxifen is a very popular medication in bodybuilding for its ability to help prevent or treat side effects from anabolic steroids. Bodybuilders use it as a part of Post Cycle Therapy (PCT) and/or as a preventative of gynecomastia (male breast tissue development). The most popular brand name of Tamoxifen Citrate is Nolvadex; however, you can find it under numerous other brand names. This is a Selective Estrogen Receptor Modulator (SERM) medication, which means that it binds to estrogen receptors in certain tissues, blocking the effects of estrogen. It is similar to Clomid (Clomiphene) – another SERM. Although it is an anti-estrogen, it is very different from Aromatase Inhibitors (AIs). AIs do not bind to estrogen receptors, blocking their activity (like SERMs), but inhibit aromatase enzymes, lowering total estrogen levels in the body (unlike SERMs such as Nolvadex). In short, Tamoxifen prevents/treats gynecomastia and helps with PCT protocols.
How Tamoxifen works?
Tamoxifen works by selectively and strongly binding to estrogen receptors in certain tissues (that’s why it is a SERM). It blocks estrogen receptors in some tissues (working as an antagonist) or may activate them in other tissues (working as an agonist). For example, it can activate estrogen receptors in the bones. This can be effective at preventing osteoporosis by maintaining bone density. Yet, it blocks estrogen from exerting its effects in the breast tissues. This can help prevent or treat gynecomastia (male breast enlargement due to high estrogen) or breast cancer (due to estrogen). Steroids often increase estrogen levels, which is why Nolvadex is so helpful at preventing/treating gynecomastia among bodybuilders. But it also blocks estrogen from reaching the hypothalamus. This stimulates the release of LH and FSH – hormones that stimulate the testicles to produce more testosterone naturally. That’s why Nolvadex is helpful as a PCT after steroid cycles.
Is Tamoxifen chemotherapy?
No, Tamoxifen is not chemotherapy. While it is often used to treat breast cancer, it works in completely different ways from chemotherapy. This is a Selective Estrogen Receptor Modulator (SERM) medication that works by treating estrogen receptor positive breast cancer by blocking estrogen’s effects in the breasts (cancer cells that require estrogen to form and grow). It works specifically only for estrogen receptor positive breast cancer (or gynecomastia). Chemotherapy refers to cancer treatment that uses powerful drugs that kill fast growing cancer cells or stop them from dividing. It doesn’t work selectively on estrogen receptors, but works throughout the entire body, attacking any rapidly dividing cells. So it kills both cancer cells and healthy cells, leading to various side effects. While Nolvdex can also lead to side effects, it is significantly safer. It is also helpful for anabolic steroid users to prevent or treat their side effects (unlike chemotherapy).
What are the worst side effects of Tamoxifen?
Tamoxifen is a highly popular medication in bodybuilding, among those who use anabolic steroids, because it helps prevent, treat, or avoid the side effects of anabolic steroids. It helps prevent or treat gynecomastia (male breast enlargement) because a lot of steroids convert into estrogen in the body. This leads to high estrogen levels, and high estrogen can lead to gynecomastia. Nolvadex prevents it. Steroids also suppress natural testosterone production. Nolvadex helps restore natural testosterone production after the cycle, as a Post Cycle Therapy (PCT) medication. Nonetheless, it is important to understand that it comes with its own risks of side effects. While they are not as common and likely to occur among bodybuilders (because they generally need lower doses and shorter cycles), side effects can still occur. Some of the worst are blood clots (thromboembolism), liver toxicity, hot flashes and sweating, mood changes and depression, and others.
What is Tamoxifen used for?
Tamoxifen is a medication that is medically used to treat estrogen-based breast cancer and reduce the risk of this breast cancer in high risk individuals. However, it is sometimes used off-label to treat or prevent gynecomastia (estrogen-based) in men. That’s why bodybuilders use it. Many steroids convert into estrogen, leading to high estrogen levels, which can cause gynecomastia. Using Nolvadex will prevent/treat gynecomastia caused by the steroids (without lowering total estrogen levels in the body, if that’s not necessary). Additionally, Tamoxifen is used as a Post Cycle Therapy (PCT) medication in bodybuilding, among steroid users. That’s because steroids suppress natural testosterone production, but this medication helps restore the body’s natural testosterone production by stimulating the release of hormones that trigger testosterone production. Additionally, it may treat infertility in males and females by inducing ovulation in women and stimulating testosterone and sperm production in men.
Does Tamoxifen cause weight gain?
Tamoxifen is not commonly associated with significant weight gain. However, some people still may experience changes in weight. It is uncommon, and weight changes related to Tamoxifen are usually minor. It all varies, depending on the individual response and many other factors. Still, this can happen because of hormonal changes, such as blocking estrogen in certain tissues, like the brain (hypothalamus), which can change hormonal balance. This can lead to water retention or changes in appetite, potentially contributing to weight gain. Fluid retention is not very common, but it may still occur. Changes in appetite can lead to consuming more food than usual, potentially contributing to weight gain. Especially that it may boost overall testosterone levels, which is likely to contribute to a boost in appetite, water retention, and muscle growth, leading to weight gain. Still, weight gain is not a very common or direct side effect of Nolvadex.
What does Tamoxifen do?
Tamoxifen (Nolvadex) is a Selective Estrogen Receptor Modulator (SERM), which means that it selectively binds to estrogen receptors in certain tissues in the body. It can either block (as an antagonist) or activate (as an agonist) estrogen receptors in different tissues. It can activate estrogen in bones (boosting bone mineral density) or block estrogen in the hypothalamus and breast tissues. This way, Nolva helps treat estrogen receptor positive breast cancer or reduce the risk of such breast cancer. Additionally, it can help prevent or treat gynecomastia due to high estrogen in men. Also, by blocking estrogen in the hypothalamus, it boosts the release of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). These hormones affect ovulation in women, as well as sperm and testosterone production in men. This helps treat infertility in both genders and helps restore natural testosterone production as a Post Cycle Therapy (PCT) in bodybuilding.
Does Tamoxifen cause hair loss?
While theoretically, Tamoxifen can somewhat contribute to hair loss, this is not a common or direct side effect. It rarely occurs only in some particular individuals. Therefore, its effects on hair are not widely discussed. It may potentially influence hair by blocking estrogen receptors in the hypothalamus, which can cause a hormonal shift. Estrogen plays a role in promoting hair growth. By blocking its effects, temporary hair thinning or shedding in some individuals can occur, but that’s not very typical and definitely not guaranteed. It may also cause hair loss by promoting the boost of testosterone – the main male androgen that can contribute to hair shedding or thinning. However, anabolic steroids themselves are more directly linked to hair loss (male pattern baldness) due to changes in hormones and a boost in androgens (which negatively affects hair follicles).
Can Tamoxifen cause weight gain?
Tamoxifen is not typically associated with significant weight gain. It can rarely occur only in sensitive individuals, those who may experience slight weight fluctuations or changes in the body. This can occur because it blocks estrogen in the hypothalamus, changing hormonal balance. This can potentially contribute to water retention, bloating, or puffiness, mistaken for weight gain, and may lead to an appetite boost. Especially because it may also boost testosterone levels, which can cause muscle growth, appetite boost, and water retention, contributing to weight gain. But weight gain due to Nolvadex is rare and not very prominent.
Do Tamoxifen side effects start immediately?
Tamoxifen side effects do not commonly start immediately after beginning its use. However, some people may experience them pretty soon after starting their administration. Also, some people may experience them sooner than others; it depends on the individual response to the medication, dosage, lifestyle, gender, age, and other factors. For some people, side effects may appear within a few days, others a few weeks, while others may not experience any noticeable side effects until after several months of use. Usually, the short-term side effects that may appear within the first few weeks are hot flashes, sweating, nausea, digestive issues, mood changes, and/or fatigue. The medium to long-term side effects that usually appear after weeks or months of use are weight fluctuations or water retention, changes in menstrual cycle (for women), joint pain or stiffness, bone health, blood clot risk, and others.
Is Tamoxifen an aromatase inhibitor?
No, tamoxifen is not an Aromatase Inhibitor (AI). This is a Selective Estrogen Receptor Modulator (SERM). Both are anti-estrogens, because both deal with high estrogen related side effects. However, they are two different types of drugs with completely different mechanisms of actions when it comes to managing estrogen-related issues. Nolvadex, as a SERM, works by blocking estrogen receptors in certain tissues. It will not decrease the overall levels of estrogen in the body; it just prevents estrogen from binding to its receptors, preventing it from exerting its activity, preventing the high estrogen related issues. Aromatase Inhibitors (AIs), such as Arimidex (anastrozole) or Aromasin (exemestane), work by blocking aromatase enzymes, which are responsible for converting androgens into estrogen. By blocking this enzyme, they reduce the overall amount of estrogen in the body. This is how they deal with high-estrogen-related issues.
What is the lowest effective dose of Tamoxifen?
The lowest effective dose of Tamoxifen depends on the condition that you are trying to treat. For example, for breast cancer treatment, a doctor most commonly prescribed 20 mg/day. Whereas they may adjust the dosage, it still remains the most common and effective starting dosage. The same dosage is used for breast cancer prevention, although some guidelines recommend a lower dosage of 10 mg/day. For Post Cycle Therapy (PCT) in bodybuilding, the lowest effective dosage is 10 mg/day. However, most often, the dosage is 40 mg/day at the beginning of PCT (to kickstart the natural testosterone production), and then 20 mg/day toward the end. But some choose to use even lower, such as 10 mg/day, to restore natural testosterone production. For female or male infertility treatment, the dosage is commonly 20 mg/day. Although some women may choose 40 mg/day for a short period.
How long does Tamoxifen stay in the body after stopping?
The time it takes for Tamoxifen (Nolvadex) to leave the body after stopping treatment can vary, depending on various factors. Dosage, lifestyle choices, individual metabolism, treatment length, and others, such as age and health, all play a role. It usually takes several weeks for the drug to be completely eliminated from the body. It is because the half-life of this product is about 5 to 7 days. Complete elimination usually takes 5 to 6 half lives. This means that it can take more than a month for tamoxifen to fully clear the system. Not to mention that there’s an active metabolite in this substance (N-desmethyltamoxifen) that has a half-life of about 14 days, which could take even longer for it to clear the system. Usually, that’s 1-2 months after the last dosage.
Where to buy Tamoxifen?
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